Direct immobilization and patterning of hyaluronic acid on hydrophilic substrates

Author

Suh, Kahp Y. ; Khademhosseini, Ali ; Yang, Jen Ming ; Eng, George ; Langer, Robert

Author_Institution

Sch. of Mech. & Aerosp. Eng., Seoul Nat. Univ., South Korea

fYear

2005

fDate

12-15 May 2005

Firstpage

331

Lastpage

332

Abstract

In this study, we describe two methods of patterning HA on various substrates including glass, silicon dioxides, poly (hydroxyethyl methacrylate) [poly (HEMA)], polystyrene cell culture dishes, and biodegradable polylactic glycolic acid (PLGA), without the use of chemical modification or with slight modification with NaOH or oxygen plasma treatment. Such versatile use of soft lithographic methods would be potentially useful for many biomedical applications.

Keywords

biochemistry; biomedical materials; cellular biophysics; lithography; molecular biophysics; polymers; proteins; tissue engineering; SiO₂; biodegradable polylactic glycolic acid; biomedical application; direct immobilization; hyaluronic acid patterning; hydrophilic substrates; polystyrene cell culture dish; soft lithographic method; Adhesives; Biodegradable materials; Biological materials; Chemical engineering; Cleaning; Glass; Plasma temperature; Proteins; Solvents; Surface treatment; Hyaluronic acid; capillary lithography; cell patterning; immobilization;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on

Print_ISBN

0-7803-8711-2

Type

conf

DOI

10.1109/MMB.2005.1548464

Filename

1548464