Multirate MPC design for a nonlinear drug infusion system

Author

Gopinath, Ravi S. ; Bequette, B. Wayne ; Roy, Rob J. ; Kaufman, Howard

Author_Institution

Dept. of Chem. Eng., Rensselaer Polytech. Inst., Troy, NY, USA

Volume

1

fYear

1994

fDate

29 June-1 July 1994

Firstpage

102

Abstract

Multivariable controller design for the regulation of blood pressure and flowrate in congestive heart failure patients is typically limited by the sample time for blood flowrate. We present a multirate model predictive control (MPC) design for the multidrug infusion problem, based on a comprehensive nonlinear model of the system. The MPC design is based on NL-QDMC, with a selective linearization method introduced to reduce computation time. External constraints on dopamine infusion specify a ´forbidden zone´ in addition to upper and lower bounds. The multirate MPC design includes a novel rule-based override that is used to avoid any infusion in this region. Simulation results are used to illustrate the performance of the controller.

Keywords

biomedical equipment; blood; linearisation techniques; multivariable control systems; nonlinear control systems; patient treatment; predictive control; blood flowrate regulation; blood pressure regulation; comprehensive nonlinear model; computation time; congestive heart failure patients; dopamine infusion; forbidden zone; lower bounds; multidrug infusion problem; multirate model predictive control design; multivariable controller design; nonlinear drug infusion system; rule-based override; selective linearization method; upper bounds; Arteries; Blood pressure; Circulatory system; Design engineering; Drug delivery; Heart; Immune system; Nonlinear equations; Predictive models; Pressure control;

fLanguage

English

Publisher

ieee

Conference_Titel

American Control Conference, 1994

Print_ISBN

0-7803-1783-1

Type

conf

DOI

10.1109/ACC.1994.751703

Filename

751703