Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow

Author

Qin, Kairong ; Xu, Zhe ; Zhang, Hui ; Xiang, Cheng ; Ge, Shuzhi Sam ; Jiang, Zonglai

Author_Institution

Inst. of Mechanobiology & Med. Eng., Shanghai Jiao Tong Univ.

fYear

2006

fDate

4-6 Oct. 2006

Firstpage

1270

Lastpage

1275

Abstract

In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface

Keywords

biological fluid dynamics; cellular biophysics; enzymes; molecular biophysics; numerical analysis; physiological models; shear flow; ATP concentration; ATP hydrolysis; adenosine triphosphate; dynamic modeling; ecto-ATPase; endothelial cells; endothelial surface; endothelium-fluid interface; mechanotransduction; shear stress; viscous shear flow; Biological system modeling; Blood; Calcium; Cells (biology); Extracellular; Fluid dynamics; Hemodynamics; Intelligent control; Stress; Surface morphology; ATP; dynamic model; endothelial cells; mechanotransduction; shear stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control, 2006 IEEE

Conference_Location

Munich

Print_ISBN

0-7803-9797-5

Electronic_ISBN

0-7803-9797-5

Type

conf

DOI

10.1109/CACSD-CCA-ISIC.2006.4776825

Filename

4776825