Title :
Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow
Author :
Qin, Kairong ; Xu, Zhe ; Zhang, Hui ; Xiang, Cheng ; Ge, Shuzhi Sam ; Jiang, Zonglai
Author_Institution :
Inst. of Mechanobiology & Med. Eng., Shanghai Jiao Tong Univ.
Abstract :
In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface
Keywords :
biological fluid dynamics; cellular biophysics; enzymes; molecular biophysics; numerical analysis; physiological models; shear flow; ATP concentration; ATP hydrolysis; adenosine triphosphate; dynamic modeling; ecto-ATPase; endothelial cells; endothelial surface; endothelium-fluid interface; mechanotransduction; shear stress; viscous shear flow; Biological system modeling; Blood; Calcium; Cells (biology); Extracellular; Fluid dynamics; Hemodynamics; Intelligent control; Stress; Surface morphology; ATP; dynamic model; endothelial cells; mechanotransduction; shear stress;
Conference_Titel :
Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control, 2006 IEEE
Conference_Location :
Munich
Print_ISBN :
0-7803-9797-5
Electronic_ISBN :
0-7803-9797-5
DOI :
10.1109/CACSD-CCA-ISIC.2006.4776825
