Ultra-high frequency IC design for intelligent genetic analysis systems

This paper outlines the intelligence and portability requirements for future genetic analysis systems tailored to fast, low cost, and large scale population studies. Methods used in current research for DNA amplification and detection are discussed. The most significant shortcomings of current practises are their lack of the programmability required to generate different heating profiles to detect the correlation between different genetic components and specific diseases. In addition, none of the existing systems have the capability to quickly compare detected DNA with a bank of DNA signatures particular to a specific disease in a low cost, portable, and label-free process. Promising techniques relying on the advances in CMOS RF and sub-THz IC design are discussed within the context of programmable and parallel DNA amplification and detection platforms. The availability of such platforms can transform the field of genetic analysis, leading to personalized medicine and therapy.