Cellular responding DNA damage: A predictive model of P53 gene regulatory networks under continuous Ion Radiation (IR)

P53, a vital anticancer gene, controls the cell cycle arrest and cell apoptosis by regulating the downstream genes and their complicated signal pathways. To simulate the investigation of the cellular response under continuous ion radiation (IR), a predictive model of P53 gene regulatory networks is proposed at single cell level. The model can be used to simulate the dynamic processes of the double-strand breaks (DSBs) generating and their repair, ataxia telangiectasia mutated (ATM) and ARF activation, as well as the oscillations in the P53-MDM2 feedback loop under continuous effect of acute IR. Especially, the model can predict the plausible outcomes of cellular responding DNA damage under different conditions.