Modelling of repeated fed-batch fermentation process for L-Lysine production

Author

Georgiev, Tz ; Todorov, K. ; Dimov, I. ; Ivanova, V. ; Kristeva, J. ; Ratkov, A.

Author_Institution

Fac. of Automatics, Tech. Univ., Sofia

fYear

0

fDate

0-0 0

Firstpage

525

Lastpage

530

Abstract

This article deals with modelling of dynamic unstructured model of variable volume fed-batch fermentation process with intensive droppings for L-lysine production. The presented approach of the investigation includes the following main procedures: description of the process by generalized stoichiometric equations; preliminary data processing and calculation of specific rates for main kinetic variables; identification of the specific rates (growth rate (mu), substrate utilization rate (nu), production rate (rho) as a second-order non-linear dynamic models; establishment and optimization of dynamic model of the process; simulation researches. MATLAB is used as a research environment

Keywords

batch processing (industrial); biotechnology; fermentation; mathematics computing; nonlinear dynamical systems; optimisation; L-lysine production; MATLAB; generalized stoichiometric equation; intensive dropping; modelling; nonlinear dynamic model; optimization; preliminary data processing; repeated fed-batch fermentation process; Amino acids; Automation; Data processing; Feeds; Kinetic theory; MATLAB; Mathematical model; Nonlinear equations; Production; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Technology Interfaces, 2006. 28th International Conference on

Conference_Location

Cavtat/Dubrovnik

ISSN

1330-1012

Print_ISBN

953-7138-05-4

Type

conf

DOI

10.1109/ITI.2006.1708536

Filename

1708536