Title :
In Silico Assessment of Nanosecond Pulse Exposures of Cells, Tissues and Organs
Author :
Gowrishankar, Thiruvallur ; Esser, Axel ; Smith, Kyle ; Weaver, James
Author_Institution :
Div. of Health Sci. & Technol., Massachusetts Inst. of Technol., Cambridge, MA
Abstract :
We have developed an in silico framework that integrates macro- and microdosimetry models, and incorporates biophysical mechanism models to estimate biochemical change resulting from exposure to nanosecond electrical pulses. This approach provides estimates of conductance changes and biochemical release/uptake within cells, local tissue regions and organs
Keywords :
biochemistry; bioelectric phenomena; biological effects of fields; biological organs; biological tissues; biomembrane transport; cellular effects of radiation; dosimetry; biochemical analysis; biophysical mechanism models; cell exposures; electric conductance estimation; in silico assessment; macrodosimetry models; membrane transport; microdosimetry; nanosecond electrical pulse exposures; organs exposure; tissue effects; Biological system modeling; Biomembranes; Cells (biology); Finite difference methods; Impedance measurement; Lattices; Nanobioscience; Plasmas; Pulse generation; Time domain analysis;
Conference_Titel :
Power Modulator Symposium, 2006. Conference Record of the 2006 Twenty-Seventh International
Conference_Location :
Arlington, VA
Print_ISBN :
1-4244-0018-X
Electronic_ISBN :
1-4244-0019-8
DOI :
10.1109/MODSYM.2006.365295
