Title :
One optimal adaptive design in clinical trials
Author :
Cao, Lei ; Tao, Jian
Author_Institution :
Sch. of Basic Sci., Changchun Univ. of Technol., Changchun, China
Abstract :
The Randomized Play-the-Winner (RPW) and the Generalized Friedman´s Urn (GFU)model are very useful in clinical trials. In this paper, a new adaptive design is proposed which is beneficial for selecting the better of two competing treatments in future. It is more reasonable that the new design of two arms considers α and β belong to GFU model as parameters rather than constants. The new design has some desirable asymptotic properties.
Keywords :
optimisation; patient treatment; statistical analysis; GFU; RPW; asymptotic properties; clinical trials; generalized Friedman urn; optimal adaptive design; randomized play-the-winner; Adaptation model; Artificial neural networks; Educational institutions; Zinc; Adaptive designs; Generalized Friedman´s Urn model; asymptotical normality; component; strong convergence;
Conference_Titel :
Computer, Mechatronics, Control and Electronic Engineering (CMCE), 2010 International Conference on
Conference_Location :
Changchun
Print_ISBN :
978-1-4244-7957-3
DOI :
10.1109/CMCE.2010.5609914
