Title :
ISCOMATRIX Application of Nanotechnology
Author :
Yao, Peng ; Jian, An
Author_Institution :
Animal Sci. & Technol. Coll., Beijing Agric. Coll., Beijing, China
Abstract :
Immunostimulatory complexes (ISCOMs), composed of antigen, saponin, cholesterol, and phospholipid, are the typical nano materials. It has the ability to hold antigen to delivery system, while ISCOMATRIX is a particulate adjuvant comprising saponin, cholesterol and phospholipid but antigen absence. The misture of antigens with ISCOMATRIX is called an ISCOMATRIX vaccine. In this paper, a new material (DC-Chol) to form ISCOMATRIX by the method of dialysis. The ISCOMATRIX is a nano materials and have the targenting effect. It has the advantage of taking the antigen to targeting cell(APCs).
Keywords :
biomedical materials; drug delivery systems; drugs; molecular biophysics; nanomedicine; nanostructured materials; DC-Chol material; ISCOMATRIX vaccine; antigen; cholesterol; delivery system; dialysis; immunostimulatory complex; nanomaterials; nanotechnology; phospholipid; saponin; Animals; Educational institutions; Immune system; Nanobioscience; Nanostructured materials; Vaccines; DC-Chol; ISCOMATRIX; Nano-materials;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.256
