Title :
Macromolecular Drug Conjugates, Metronidazole-Cyclodextrin Prodrugs
Author :
Wang, Zhizhong ; Liu, Mengying
Author_Institution :
Sch. of Pharmacy, Ningxia Med. Univ., Yinchuan, China
Abstract :
The antimicrobial drug metronidazole was covalently attached to β-cyclodextrin by -CH2-CO-bridges. The preliminary release behavior of metronidazole in the cecal fluids of rats was studied at 37 °C. Metronidazole was nearly released 60% from the macromolecular conjugates after 24 h in the cecal fluids of rats, probably via the biodegradation by glycosidases and hydrolases.
Keywords :
biochemistry; biological organs; drugs; molecular biophysics; β-cyclodextrin; antimicrobial drug; biodegradation; cecal fluids; glycosidases; hydrolases; macromolecular drug conjugates; metronidazole-cyclodextrin prodrugs; release behavior; temperature 37 C; time 24 h; Colon; Drug delivery; Drugs; Fluids; Rats; conjugate; cyclodextrin; hydrolysis; metronidazole;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.267
