Nano-scale biomechanical analyzer for studying stimulus dependent self-assembly of actin filament

Author

Shimada, N. ; Ikeuchi, M. ; Ikuta, K.

Author_Institution

Univ. of Tokyo, Tokyo, Japan

fYear

2014

fDate

26-30 Jan. 2014

Firstpage

921

Lastpage

924

Abstract

We have developed nano-scale mechanical analysis system by using “optically driven nano-beam” to measure elasticity of self-assembled actin filament under dynamic mechanical stimulus. In this report, we worked on developing a new nano-beam to specifically capture actin on its surface. By using the new nano-beam, we have successfully measured elasticity of self-assembled actin filament in water. The nano-mechanical analysis system unravels cell life phenomenon which can´t be dealt with through conventional methodologies.

Keywords

biological techniques; biomechanics; cellular biophysics; elasticity; molecular biophysics; nanobiotechnology; nanomechanics; proteins; self-assembly; water; cell life phenomenon; conventional methodologies; dynamic mechanical stimulus; nanomechanical analysis system; nanoscale biomechanical analyzer; nanoscale mechanical analysis system; optically driven nanobeam; self-assembled actin filament elasticity; stimulus dependent self-assembly; water; Biomedical optical imaging; Charge carrier processes; Optical device fabrication; Optical imaging; Optical sensors; Proteins; Resins;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on

Conference_Location

San Francisco, CA

Type

conf

DOI

10.1109/MEMSYS.2014.6765792

Filename

6765792