Title :
Nano-scale biomechanical analyzer for studying stimulus dependent self-assembly of actin filament
Author :
Shimada, N. ; Ikeuchi, M. ; Ikuta, K.
Author_Institution :
Univ. of Tokyo, Tokyo, Japan
Abstract :
We have developed nano-scale mechanical analysis system by using “optically driven nano-beam” to measure elasticity of self-assembled actin filament under dynamic mechanical stimulus. In this report, we worked on developing a new nano-beam to specifically capture actin on its surface. By using the new nano-beam, we have successfully measured elasticity of self-assembled actin filament in water. The nano-mechanical analysis system unravels cell life phenomenon which can´t be dealt with through conventional methodologies.
Keywords :
biological techniques; biomechanics; cellular biophysics; elasticity; molecular biophysics; nanobiotechnology; nanomechanics; proteins; self-assembly; water; cell life phenomenon; conventional methodologies; dynamic mechanical stimulus; nanomechanical analysis system; nanoscale biomechanical analyzer; nanoscale mechanical analysis system; optically driven nanobeam; self-assembled actin filament elasticity; stimulus dependent self-assembly; water; Biomedical optical imaging; Charge carrier processes; Optical device fabrication; Optical imaging; Optical sensors; Proteins; Resins;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on
Conference_Location :
San Francisco, CA
DOI :
10.1109/MEMSYS.2014.6765792
