The Synthesis of Evodiamine

Author

Wang, Cheng-xue ; Xiong, Yu

Author_Institution

Sch. of Chem. Eng., Changchun Univ. of Technol., Changchun, China

fYear

2012

fDate

28-30 May 2012

Firstpage

633

Lastpage

636

Abstract

The e-carboline compound and evodiamine were synthesized with improved Bischler-Napieralski-type and Diels-Alder-type reactions by taking tryptamine and N-methyl anthranilic acid as starting materials, enjoying the characteristics of few steps, simple ness, mild reaction conditions, high productivity and less pollution etc. Conduct elementary analyses on the resulting compounds and characterize them with analyzing means such as IR, ESI-MS, ¹H NMR and ¹³C NMR. In addition, regular MTT cytotoxicity tests were also performed, and three different time periods were formulated to determine its IC50.

Keywords

chemical reactions; drugs; infrared spectra; mass spectra; materials testing; nuclear magnetic resonance; organic compounds; ¹³C NMR method; ¹H NMR method; Bischler-Napieralski-type reaction; Diels-Alder-type reaction; ESI-MS method; IR method; MTT cytotoxicity test; N-methyl anthranilic acid; beta-carboline compound; elementary analysis; evodiamine synthesis; infrared spectroscopy; mass spectroscopy; nuclear magnetic resonance; tryptamine; Chemicals; Compounds; Detectors; Materials; Nuclear magnetic resonance; Productivity; 3; 4-dihydro-¦Â-carboline; Diels-Alder-type; Evodiamine; MTT;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on

Conference_Location

Macau, Macao

Print_ISBN

978-1-4577-1987-5

Type

conf

DOI

10.1109/iCBEB.2012.446

Filename

6245199