Title :
Real-time PCR and Immunohistochemistry Detecting the Expression of PETA-3 in Breast Cancer and the Clinical Significance
Author :
Liu, Ting ; Zhou, Li ; Rong, Wei
Author_Institution :
Dept. of Pathology, Qiqihar Med. Univ., Qiqihar, China
Abstract :
Objective: To observe the relationship between the expression of PETA-3 and clinicopathological factors in breast cancer. Methods: 40 breast cancer samples were detected by the real-time PCR and immunohistochemical staining to analyze the expression of PETA-3. The relationship between the expression of and clinicopathological factors was analyzed. Results: Compared to that in the adjacent tissues, the expression of PETA-3mRNA was markedly increased in breast cancer tissues. PETA-3 expression was significantly higher in metastatic breast cancer than in non-metastatic tumors. Furthermore PETA-3 expression levels of breast cancer were correlated with estrogen receptor status. Conclusions: Increased expression of PETA-3 suggests its involvement in the pathogenesis and metastasis of breast cancer.
Keywords :
RNA; biochemistry; biological techniques; cancer; molecular biophysics; patient diagnosis; tumours; PETA-3 expression detection; PETA-3mRNA expression; breast cancer clinicopathological factors; breast cancer metastasis; breast cancer pathogenesis; breast cancer tissues; estrogen receptor status; immunohistochemical staining; immunohistochemistry; metastatic breast cancer; nonmetastatic tumors; polymerase chain reaction; real time PCR; Breast cancer; Erbium; Immune system; Metastasis; Real time systems; Tumors; Breast cancer; PETA-3; immunohistochemistry; real-time PCR;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.330
