Title :
TGF-Beta and CTGF Mediated Signal Transduction Pathway and Fibrosis
Author :
Tian, Jingrui ; Yang, Fang ; Liu, Huiqin
Author_Institution :
Libr., Hebei United Univ., Tangshan, China
Abstract :
Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.
Keywords :
biological tissues; cellular transport; diseases; molecular biophysics; proteins; CTGF expression; CTGF mediated signal transduction pathway; TGF-beta downstream factor; TGF-beta mediated fibrosis; TGF-beta mediated signal transduction pathway; cell factors; connective tissue growth factor; fibrous function; signal transduction pathways; transforming growth factor beta; Connective tissue; Electronic countermeasures; Fibroblasts; Humans; Lungs; Proteins; CTGF; TGF-?; fibrosis; signal transduction;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.397
