DocumentCode
2682185
Title
Critical Boolean networks require minimal intervention rate
Author
Vahedi, Golnaz ; Shmulevich, Ilya ; Liu, Wenbin ; Dougherty, Edward
Author_Institution
Dept. of Electr. & Comput. Eng., Texas A&M Univ., College Station, TX, USA
fYear
2009
fDate
17-21 May 2009
Firstpage
1
Lastpage
2
Abstract
A prime objective of modeling gene regulatory networks is the identification of potential targets for therapeutic intervention. To this end, it is crucial to understand the structure-dynamics relationships in biological networks. In this work, we investigate the relationship between the structure of gene regulatory networks modeled as Boolean networks and the benefit-to-intervention-rate ratio of optimal intervention strategies derived for them.
Keywords
Boolean algebra; biology computing; genetics; molecular biophysics; patient treatment; biological networks; critical Boolean networks; gene regulatory networks; optimal intervention; therapeutic intervention; Bioinformatics; Biological system modeling; Biology computing; Chaos; Computer networks; Genomics; Optimal control; Stability; Steady-state; Systems biology;
fLanguage
English
Publisher
ieee
Conference_Titel
Genomic Signal Processing and Statistics, 2009. GENSIPS 2009. IEEE International Workshop on
Conference_Location
Minneapolis, MN
Print_ISBN
978-1-4244-4761-9
Electronic_ISBN
978-1-4244-4762-6
Type
conf
DOI
10.1109/GENSIPS.2009.5174341
Filename
5174341
Link To Document