Title :
Fabrication of Nanopatterned Surfaces for Tissue Engineering
Author :
Jeong, Eun Ju ; Lee, Jin Wook ; Yeon, Soo-Jeong ; Lee, Jae-Won ; Kwark, Young-Je ; Rhee, Sang-Hoon ; Park, Won Ho ; Kim, Seung Hyun ; Lee, Kuen Yong
Author_Institution :
Dept. of Bioeng., Hanyang Univ., Seoul, South Korea
Abstract :
The surface nanotopography of polymer substrates is a critical factor to regulate cellular behavior in tissue engineering approaches. In this study, nanopatterned surfaces were generated via self-assembly of polystyrene-b-poly(ethylene oxide)/dodecylbenzenesulfonic acid complex systems to control preosteoblast phenotype in vitro. Polystyrene domain sizes under 100 nm strongly affected the adhesion, proliferation, and differentiation of preosteoblasts cultured on the surfaces, irrespective of the same center-to-center distance between the domains. This approach may provide a useful means to design and develop novel polymer substrates for tissue engineering applications.
Keywords :
adhesion; biomechanics; cellular biophysics; nanofabrication; nanopatterning; nanostructured materials; polymer blends; self-assembly; surface topography; tissue engineering; cellular behavior; center-to-center distance; nanopatterned surfaces; polymer substrates; polystyrene domain sizes; polystyrene-b-poly(ethylene oxide)-dodecylbenzenesulfonic acid complex systems; preosteoblast phenotype in vitro; preosteoblasts adhesion; preosteoblasts differentiation; preosteoblasts proliferation; self-assembly; size 100 nm; surface nanotopography; tissue engineering; Adhesives; Cells (biology); Polymers; Self-assembly; Surface morphology; Surface topography; Tissue engineering; block copolymer; nanopattern; nanotopography; polymer surface; self-assembly; tissue engineering;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.220
