Research of controlling connection systems of cell macromolecular mechanisms by method of dielectrometry in the MM range of radiowaves

Research on how macromolecular complexes work in functioning cells during transmembrane transmission of a signal, during growth and regeneration, immune resistance and in many other fields, enables one to obtain information about the state of their molecular mechanisms. The study of the structurally functional role of the hydrate environment of macromolecules and their complexes at different levels of living organization from a macromolecule up to a cell allows one to find a solution of this problem. The authors have studied with the help of the method of dielectrometry using mm-range radio waves (EHF-dielectrometry) in the field of the dispersion of free water. The development of this method was begun with a study of the condition of the water component of biosystems and hydration parameters of a macromolecule with the use of mm-range radiowaves in the region of dispersion of free water. These researches were carried out over 20 years in the Institute of Radiophysics and Electronics of the National Academy of Sciences of Ukraine. As a result of the conducted complex of works a common model of macromolecular hydration was constructed which was quantitatively compared with their space organization using the International Protein Data Bank of X-ray diffraction analysis