Title :
Automated hemodynamic regulation with model predictive control
Author :
Aufderheide, Brian ; Rao, Ramesh R. ; Bequette, B. Wayne
Author_Institution :
Dept. of Chem. Eng., Rensselaer Polytech. Inst., Troy, NY, USA
Abstract :
A multiple model adaptive predictive controller is designed to regulate mean arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive drugs. The algorithm uses a multiple model adaptive approach in a model predictive control framework to account for inter- and intra-patient variability and explicitly handle drug rate constraints. The controller is evaluated on canines that were pharmacologically altered to exhibit symptoms of hypertension and depressed cardiac output
Keywords :
biocontrol; cardiovascular system; closed loop systems; drug delivery systems; haemodynamics; model reference adaptive control systems; predictive control; pressure control; automated haemodynamic regulation; canines; cardiac output; circulatory model; closed loop simulation; controller design; critical care subjects; depressed cardiac output; drug infusion systems; drug rate constraints; hypertension; inotropic drugs; inter-patient variability; intra-patient variability; mean arterial pressure; model predictive control; multiple model adaptive predictive controller; vasoactive drugs; Adaptive control; Automatic control; Blood pressure; Drugs; Hemodynamics; Hypertension; Predictive control; Predictive models; Pressure control; Programmable control;
Conference_Titel :
Bioengineering Conference, 1999. Proceedings of the IEEE 25th Annual Northeast
Conference_Location :
West Hartford, CT
Print_ISBN :
0-7803-5486-9
DOI :
10.1109/NEBC.1999.755770
