Title :
Cardiopulmonary bypass effects on platelets adhesion to biomaterials
Author :
Iden, Cheryl D. ; Scranton, Victoria L. ; Hammond, Jonathan ; Goodman, Steven L.
Author_Institution :
Dept. of Clinical Eng., Univ. of Connecticut Health Center, Farmington, CT, USA
Abstract :
It is our interest to examine how cardiopulmonary bypass (CPB) influences platelet adhesion and thrombosis on the synthetic materials used in CPB and in implantable cardiovascular prosthetics. CPB appears to have significant effects on platelet interaction with commonly used clinical biomaterials, including altering platelet spreading, formation of thrombi and potentially inducing the creation of platelet microparticles
Keywords :
adhesion; biomedical materials; blood; cardiovascular system; haemorheology; prosthetics; cardiopulmonary bypass effects; heart valve materials; platelet microparticles; platelet spreading; platelets adhesion to biomaterials; synthetic biomaterials; thrombosis; Adhesives; Blood; Cardiology; Heart valves; In vitro; Organic materials; Prosthetics; Scanning electron microscopy; Surface morphology; Surgery;
Conference_Titel :
Bioengineering Conference, 1999. Proceedings of the IEEE 25th Annual Northeast
Conference_Location :
West Hartford, CT
Print_ISBN :
0-7803-5486-9
DOI :
10.1109/NEBC.1999.755771
