Title :
A modified ecarin clotting time test monitors the anticoagulant effects of hirudin
Author :
Gandhi, Arpita ; Kristol, David ; Spillert, Charles R.
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
A rapid blood clotting test for monitoring the thrombin inhibiting activity of the drug hirudin is described. This test, a modified ecarin clotting time may enable the monitoring of a patient´s hirudin dosage so that a safe, therapeutic level is achieved. The results show that there was an increase in clotting time with an increased level of hirudin. The data demonstrates a linear correlation between ecalin clotting time prolongation and hirudin content. Each clotting time is significantly prolonged (p<0.01) in comparison to the clotting time at lower concentrations
Keywords :
cardiovascular system; coagulation; haemodynamics; patient monitoring; patient treatment; anticoagulant effects; drug dosage monitoring; hirudin; linear correlation; modified ecarin clotting time test; rapid blood clotting test; safe therapeutic level; thrombin inhibiting activity monitoring; Biomedical monitoring; Blood; Coagulation; Drugs; In vitro; Medical tests; Patient monitoring; Pharmaceutical technology; Proteins; Testing;
Conference_Titel :
Bioengineering Conference, 1999. Proceedings of the IEEE 25th Annual Northeast
Conference_Location :
West Hartford, CT
Print_ISBN :
0-7803-5486-9
DOI :
10.1109/NEBC.1999.755782
