Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning

Author

Tsai, C.S. ; Mao, R.W. ; Yun Zhu ; Chien, Eric ; Maduzia, James ; Brenner, Markus ; Mahon, S. ; Mukai, D. ; Jangwoen Lee ; Yoon, Daekeun ; Berney, Tanya ; Tsai, Shih Chang ; Boss, G. ; Patterson, Stacy

Author_Institution

Dept. of Electr. Eng. & Comp. Sci., Univ. of California, Irvine, Irvine, CA, USA

fYear

2012

fDate

7-10 Oct. 2012

Firstpage

1632

Lastpage

1634

Abstract

Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.

Keywords

aerosols; nozzles; patient treatment; pneumodynamics; toxicology; antidote inhalation; cobinamide antidote solution; cyanide poisoning; detoxification; hand held monodisperse aerosol inhaler; high throughput monodisperse aerosol inhaler; intra muscular treatment; intra venous treatment; rabbit model; silicon based ultrasonic nozzle; ultrasonic monodisperse aerosol inhaler; Acoustics; Aerosols; Drugs; Face; Lungs; Rabbits; Throughput; Fourier-horn ultrasonic nozzles; cobinamide antidote; cyanide poisoning and detoxification; monodisperse aerosol inhaler;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2012 IEEE International

Conference_Location

Dresden

ISSN

1948-5719

Print_ISBN

978-1-4673-4561-3

Type

conf

DOI

10.1109/ULTSYM.2012.0409

Filename

6562116