On-chip enucleation of oocyte by magnetically driven microtools with ultrasonic vibration

Author

Hagiwara, Masaya ; Kawahara, Tomohiro ; Feng, Lin ; Yamanishi, Yoko ; Arai, Fumihito

Author_Institution

Dept. of Mech. Sci. & Eng., Nagoya Univ., Nagoya, Japan

fYear

2011

fDate

9-13 May 2011

Firstpage

2680

Lastpage

2685

Abstract

This paper describes an innovative driving method for magnetically driven microtools (MMT). 1.1 μm positioning accuracy of the MMT was obtained by applying a piezoelectric ceramic, which induced nanoscale vibration to the microfluidic chip, and reducing the friction on the MMT. Using this drive method, the enucleation process was conducted by dual-arm MMT. Permanent magnets are used to supply the driving power to the MMT allowing sufficient positioning accuracy to cut oocytes precisely. The nucleus was cut within 10 s, and the removed area was less than 25% of the original oocyte.

Keywords

bioMEMS; biological techniques; cellular biophysics; friction; lab-on-a-chip; microfluidics; permanent magnets; piezoceramics; ultrasonic applications; dual-arm MMT; friction; magnetically driven microtool; microfluidic chip; nanoscale vibration; on-chip enucleation; oocyte; permanent magnets; piezoelectric ceramics; time 10 s; ultrasonic vibration; Accuracy; Acoustics; Ceramics; Friction; Microfluidics; Permanent magnets; Vibrations;

fLanguage

English

Publisher

ieee

Conference_Titel

Robotics and Automation (ICRA), 2011 IEEE International Conference on

Conference_Location

Shanghai

ISSN

1050-4729

Print_ISBN

978-1-61284-386-5

Type

conf

DOI

10.1109/ICRA.2011.5979930

Filename

5979930