Can a neural circuit support multiple signal patterns?

Author

Wolpert, S.

Author_Institution

Sch. of Sci., Eng. & Technol., Penn State Univ., Harrisburg, PA, USA

Volume

3

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

1385

Abstract

In this study, a comprehensive cell-by-cell, synapse-by-synapse model of a living central pattern generator network was implemented in analog VLSI CMOS. In the final model, rhythms and waveforms for membrane potential in each cell were seen to compare faithfully and regularly with those of their living counterparts with nominal settings, but as key cell parameters were varied, the network assumed alternate signal patterns and rhythms. This suggests that neuromorphic structure is not enough to specify the signals that will occur in a nerve circuit. Cell parameters must be replicated as well

Keywords

CMOS analogue integrated circuits; VLSI; bioelectric potentials; biomedical electronics; biomembranes; cellular biophysics; neurophysiology; physiological models; alternate signal patterns; analog VLSI CMOS; cell membrane potential; cell parameters; comprehensive cell-by-cell synapse-by-synapse model; living central pattern generator network; membrane potential; nerve circuit; neuromorphic structure; neurophysiological model; rhythms; waveforms; Biological system modeling; Biomembranes; CMOS technology; Circuit testing; Mathematical model; Neuromorphics; Oscillators; Rhythm; Semiconductor device modeling; Very large scale integration;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.756637

Filename

756637