DocumentCode :
2695347
Title :
The acoustic properties comparison of lipid microbubbles at high ultrasound frequencies
Author :
Chao Sun ; Sboros, Vassilis ; Butler, Mairead ; Moran, Carmel M.
Author_Institution :
Med. Phys., Univ. of Edinburgh, Edinburgh, UK
fYear :
2012
fDate :
7-10 Oct. 2012
Firstpage :
413
Lastpage :
416
Abstract :
The effect of microbubble size on the acoustic properties of ultrasound contrast agents has been studied over the clinical frequency range (<;10MHz), but comparable research at high frequency is limited. As a further development of high frequency ultrasound in preclinical, intravascular and superficial tissue imaging, this study quantified the attenuation and contrast to tissue ratio (CTR) of two commercial lipid UCAs, Definity and SonoVue, at three populations over the frequency range 12-31 MHz at 20 ± 1 °C using a broadband substitution technique. The attenuation and CTR of the two contrast agents in the native and large microbubbles (MBs) population were found to decrease with frequency and the magnitude of the values for the two contrast agents was comparable at the same number concentration. Over this frequency range, large MBs contributed more than 5dB to the CTR than from small MBs.
Keywords :
bioacoustics; biological tissues; biomedical ultrasonics; bubbles; lipid bilayers; CTR; SonoVue; acoustic properties; contrast to tissue ratio; frequency 12 MHz to 31 MHz; high ultrasound frequency; intravascular tissue imaging; lipid microbubble size; superficial tissue imaging; ultrasound contrast agents; Acoustics; Attenuation; Attenuation measurement; Sociology; Statistics; Transducers; Ultrasonic imaging;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2012 IEEE International
Conference_Location :
Dresden
ISSN :
1948-5719
Print_ISBN :
978-1-4673-4561-3
Type :
conf
DOI :
10.1109/ULTSYM.2012.0102
Filename :
6562452
Link To Document :
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