Continuous ex vivo lactate monitoring in whole blood

Author

Gfrerer, R.J. ; Wach, P. ; Brunner, G. ; Trajanoski, Z. ; Schaupp, L. ; Leitner, B. ; Skraba, F. ; Jobst, G. ; Moser, I. ; Urban, G. ; Schumacher, M. ; Sendlhofer, G. ; Pieber, T.R.

Author_Institution

Dept. of Biophys., Graz Univ. of Technol., Austria

Volume

6

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

2354

Abstract

The objective of this study was to evaluate a system for continuous measurement of lactate in whole blood. The continuously withdrawn samples were obtained by means of two different methods for the prevention of blood coagulation. The first one dealt with a double lumen catheter. The tip of the catheter was rinsed with heparin solution via the inner lumen and the outer lumen was used to collect the blood samples. The second method used a heparin coated single lumen system which was inserted in a peripheral vein. A sensor flow chamber incorporating a thin-film amperometric glucose/lactate sensor was connected to the blood withdrawal system. The system was evaluated in 5 bicycle ergometer tests which demonstrated the stability and the accuracy of the sensors during the required period of at least 1½ hours. In conclusion, on-line ex vivo lactate monitoring in whole blood is feasible with systems of this kind

Keywords

biochemistry; biomedical equipment; biomedical measurement; biosensors; blood; electrochemical sensors; microsensors; patient monitoring; bicycle ergometer tests; blood withdrawal system; coagulation prevention; continuous ex vivo lactate monitoring; continuous lactate measurement; double lumen catheter; heparin coated single lumen system; heparin solution; on-line data acquisition; on-line monitoring; peripheral vein; sensor flow chamber; thin film microbiosensors; thin-film amperometric glucose/lactate sensor; whole blood; Amperometric sensors; Bicycles; Blood; Catheters; Coagulation; Monitoring; Sensor systems; Sugar; Thin film sensors; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.756789

Filename

756789