Trajectory analysis in human epileptiform discharges of temporal lobe origin

Heuristic analysis of interictal single spike and sharp wave (SSW) voltage topography in five cases of partial complex epilepsy of temporal lobe origin leads to the following preliminary conclusions. The SSWs examined revealed EEG voltage topographic evidence to suggest both local and distant involvement of temporal lobe structures. Limited local involvement was predominant in all the cases, but evidence of distant involvement including contralateral activation was seen in the most medically refractory case. Sophisticated EEG analysis can facilitate localization of human epileptic phenomena which may serve as a robust model of human neuronal networks