Mouse genome informatics in a new age of biological inquiry

Author

Bult, Carol J. ; Richardson, Joel E. ; Blake, Judith A. ; Kadin, James A. ; Ringwald, Martin ; Eppig, Janan T. ; Baldarelli, R.M. ; Baya, M. ; Beal, J.S. ; Begley, D.A. ; Boddy, W.J. ; Bradt, D.W. ; Butler, N.E. ; Chu, T. ; Corbani, L.E. ; Corradi, J. ; D

Author_Institution

Jackson Lab., Bar Harbor, ME, USA

fYear

2000

fDate

2000

Firstpage

29

Lastpage

32

Abstract

Data integration is key to knowledge discovery in the age of genomics and represents a major, long-standing challenge for the genome informatics community. Integration of data across heterogeneous genome databases requires the identification of common data entities and mechanisms to ensure referential integrity and persistence of these common entities even as our understanding of their biological properties changes. The Mouse Genome Informatics (MGI) database group employs multiple strategies for achieving data integration and maintaining inter-connectedness with other databases, including: (1) the use of permanent, unique accession IDs for identifying core data entities, (2) the application of nomenclature standards for naming genes and strains of mice, and (3) the development and implementation of controlled vocabularies and ontologies to ensure semantic consistency of biological concepts within and across model organism databases

Keywords

biology computing; data integrity; data mining; distributed databases; genetics; nomenclature; scientific information systems; standards; vocabulary; zoology; accession IDs; biological concepts; biological inquiry; biological properties; common data entities; controlled vocabularies; core data entities; data integration; database interconnectedness; gene naming; genomics; heterogeneous genome databases; knowledge discovery; model organism databases; mouse genome informatics; mouse strains; nomenclature standards; ontologies; referential integrity; semantic consistency; Bioinformatics; Capacitive sensors; Databases; Genomics; Informatics; Intrusion detection; Mechanical factors; Mice; Standards development; Strain control;

fLanguage

English

Publisher

ieee

Conference_Titel

Bio-Informatics and Biomedical Engineering, 2000. Proceedings. IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

0-7695-0862-6

Type

conf

DOI

10.1109/BIBE.2000.889586

Filename

889586