DocumentCode :
2706336
Title :
Self organizing maps for class discovery in the quantitative colocalization analysis feature space
Author :
Rivas-Perea, Pablo ; Rosiles, Jose Gerardo ; Qian, Wei
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Texas, El Paso, TX, USA
fYear :
2009
fDate :
14-19 June 2009
Firstpage :
2678
Lastpage :
2684
Abstract :
Quantitative colocalization analysis in fluorescent microscopy imaging is a promising procedure used to perform functional protein analysis. Images acquired are degraded, and the features extracted are affected by this degradation. Moreover, the classification of the data becomes uncertain. In this paper, we address an application of SOM to a clustering problem formulated via feature extraction from multichannel fluorescence microscopy. First we describe the features that are extracted. Second, we use the PCA/KLT to un-correlate the data in the hyperplane; and Third, SOM network is trained to find and visualize the clusters (classes) in the data. The SOM model shows the existence of two classes, implying it is possible to design a classifier that distinguishes between images with co-localized structures and without them. We provide quantitative proof of the liability and discriminant capabilities of the feature space.
Keywords :
biomedical optical imaging; feature extraction; fluorescence; medical image processing; optical microscopy; pattern clustering; principal component analysis; proteins; self-organising feature maps; PCA-KLT; clustering problem; data classification; feature extraction; functional protein analysis; multichannel fluorescence microscopy imaging; quantitative colocalization analysis feature space; self organizing maps; Data mining; Degradation; Feature extraction; Fluorescence; Image analysis; Microscopy; Performance analysis; Principal component analysis; Proteins; Self organizing feature maps;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Neural Networks, 2009. IJCNN 2009. International Joint Conference on
Conference_Location :
Atlanta, GA
ISSN :
1098-7576
Print_ISBN :
978-1-4244-3548-7
Electronic_ISBN :
1098-7576
Type :
conf
DOI :
10.1109/IJCNN.2009.5178617
Filename :
5178617
Link To Document :
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