Elastin-like polypeptide-doxorubicin conjugates for cancer therapy

Author

Dreher, Matthew ; Raucher, Drazen ; Balu, Narayanan ; Colvin, Michael ; Hudeman, S. ; Chilkoti, Ashutosh

Author_Institution

Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

524

Abstract

Thermally responsive elastin-like polypeptides (ELP) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid labile bond. The thermal properties, release of doxorubicin, uptake of ELP, cytotoxicity and cellular localization of ELP-doxorubicin conjugates were investigated in this study.

Keywords

DNA; biochemistry; biothermics; cancer; cellular transport; patient treatment; polymers; proteins; tumours; 0 to 1 week; 37 C; 42 C; 7 day; acid labile bond; cancer therapy; cellular localization; cytotoxicity; drug delivery; elastin-like polypeptide-doxorubicin conjugates; pH-controlled release; recombinant DNA techniques; thermal properties; thermally responsive polypeptides; thermosensitive polymers; Bonding; Cancer; DNA; Drugs; Hyperthermia; Medical treatment; Neoplasms; Optical buffering; Optical scattering; Plasma temperature;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1136930

Filename

1136930