Heart rate variability in rats with aldosterone-induced chronic heart failure

Author

Raphisak, P. ; de Jongh Curry, A. ; Malkin, R.A. ; Schuckers, S.A.C.

Author_Institution

Lane Dept. of Comput. Sci. & Electr. Eng., West Virginia Univ., Morgantown, WV, USA

Volume

1

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

228

Abstract

The renin-angiotensin-aldosterone system contributes to the pathophysiology of chronic heart failure. In this study, chronic heart failure is gradually induced in uninephrectomized rats (n = 4) by aldosterone infusion (0.75 μg/h) and high Na and low Mg diet for four weeks followed up by high Na and low Mg diet alone for an additional six weeks. A control rat (n = 1) is untreated and unoperated. Electrocardiograms were recorded continuously during the entire experiment. Time and frequency domain heart rate variability (HRV) parameters are computed to study the long-term trends of heart rate and HRV. The results show that aldosterone infusion decreases heart rate and circadian variability in the treatment rats. After stopping aldosterone infusion, heart rate increases with less circadian variability. ANOVA indicates change of heart rate (p < 0.001) during and after aldosterone infusion periods (within each treatment rat).

Keywords

diseases; electrocardiography; magnesium; medical signal processing; patient diagnosis; sodium; 4 week; 6 week; ANOVA; Mg; Na; aldosterone; chronic heart failure; circadian variability; electrocardiograms; heart rate variability; pathophysiology; rats; Biomedical engineering; Computer science; Condition monitoring; Electrocardiography; Frequency domain analysis; Heart rate; Heart rate variability; Myocardium; Patient monitoring; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279584

Filename

1279584