A 2D analysis of oxygen transportation in a novel bioreactor based on oxygen carrier for bio-artificial liver support system

Author

Duan, Mei Mei ; Wu, Chang Zhe ; Huo, Xiao Lin ; Li, Ming

Author_Institution

Inst. of Electr. Eng., Beijing, China

fYear

2011

fDate

3-5 Nov. 2011

Firstpage

123

Lastpage

126

Abstract

Bioreactor (BR) is the key component of bio-artificial liver support system (BALSS). Sufficient mass transfer in BR is of great importance for hepatocytes and is essential to BALSS´ fine quality. In this paper, a mathematical model describing oxygen distribution in a suspension BR with perfluorocarbons (PFC) called oxygen carrier was developed to obtain the most efficient BR operating parameters. The 2D model is based on the geometry of BR operated under unsteady-state conditions, and the BR which rotates periodically has two inlets and outlets working alternatively. The model equations are solved using the finite element software (Fluent). The calculated results of oxygen distribution showed that 200 ml/min to 400 ml/min inlet velocity with 0.3 min to 0.5 min BR rotation period could lead to an efficient oxygen distribution.

Keywords

artificial organs; bioreactors; finite element analysis; liver; mass transfer; suspensions; BALSS; Fluent finite element software; bioartificial liver support system; bioreactor geometry; bioreactor mass transfer; hepatocytes; mathematical model; oxygen transportation 2D analysis; perfluorocarbon oxygen carrier; suspension bioreactor oxygen distribution; Biological system modeling; Fluid flow; Mathematical model; Numerical models; Oxygen; Plasmas; Suspensions;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioelectronics and Bioinformatics (ISBB), 2011 International Symposium on

Conference_Location

Suzhou

Print_ISBN

978-1-4577-0076-7

Type

conf

DOI

10.1109/ISBB.2011.6107661

Filename

6107661