Functional neuroimaging by using an implantable CMOS multimodal device in a freely-moving mouse

We have developed implantable complementary metal oxide semiconductor (CMOS) multimodal devices to observe various neural activities in the brain. The devices, biomedical photonic large scale integration (BpLSI), have an image sensing array, light emitting diodes (LEDs), and an absorbing filter to enable a real-time fluorescence imaging. Additionally, BpLSI can equip with electrodes, a cannula, and an optical fiber for various applications. Here, we report three applications of BpLSI for freely-moving mice to visualize serine-protease activities in the hippocampus, to monitor kinetic alterations of dopaminergic-fibers in the striatum, and to obtain physiological responses with broad scope in the visual cortex.