A silicon pancreatic beta cell based on the phantom bursting model

Author

Deep, Harkanwal ; Georgiou, Pantelis ; Toumazou, Christofer

Author_Institution

Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK

fYear

2011

fDate

10-12 Nov. 2011

Firstpage

273

Lastpage

276

Abstract

In this paper a bio-inspired silicon beta cell implementation based on the phantom bursting model is presented. The advantage of this model is that it can show wider range of bursting behaviour compared to previously implemented models which only exhibit a single type of bursting. This allows for design of a more physiological artificial pancreas. Designed a typical 0.35 μm process, this silicon beta cell is capable of exhibiting fast, medium and slow bursting by changing a value of single parameter allowing burst periods of up to 45 seconds. Using multiple burst periods allows tuning of the cell according to a diabetic subjects insulin requirements.

Keywords

CMOS integrated circuits; artificial organs; biomedical electronics; cellular biophysics; medical control systems; patient care; CMOS process; bioinspired silicon beta cell implementation; bursting behaviour; diabetis; insulin requirements; phantom bursting model; physiological artificial pancreas; silicon pancreatic beta cell; Diabetes; Equations; Insulin; Integrated circuit modeling; Mathematical model; Phantoms; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE

Conference_Location

San Diego, CA

Print_ISBN

978-1-4577-1469-6

Type

conf

DOI

10.1109/BioCAS.2011.6107780

Filename

6107780