Design and electro-thermal simulation for PCR silicon chip

The main goal of this study was to analyse the temperature uniformity and distribution on the micro polymerase chain reaction-PCR chip, the temperature distribution of DNA sample, and the transient temperature difference between the heater and DNA sample. This study used finite element analysis to simulate the temperature characteristics of the PCR on a silicon chip. The microreactor for polymerase chain reaction of DNA offers the advantage of small dimensions of the probe (micro, nanoliters), which lead to a faster heating and cooling, and, consequently, a reduced time of analysis. The micro-reactor could be easily integrated in a more complex system like lab-on chip.