Elastic Properties Exploration of In Vitro Cultured Microscopic Cells based on Haptic Sensing

Author

Boukallel, M.. ; Girot, M. ; Régnier, S.

Author_Institution

Lab. de Robotique de Paris, Univ. Pierre et Marie Curie, Paris

fYear

2006

fDate

10-12 July 2006

Firstpage

31

Lastpage

35

Abstract

This paper deals with the design of a micro-force sensing device for biomechanical characterization of biological samples. This device combines (SPM) techniques and advanced robotics approaches and allows to carry out in vitro prolonged observations as well as biomechanical characterization experiments. Elastic properties of biological samples are reflected to the macroscale during the mechanical characterization process by means of a haptic sensing device. Non-linear elasticity theory formalism is used in order to achieve realistic elastic rendering. Mechanical characterization experiments are conducted on human tumoral Epithilial Hella cells in order to demonstrate the efficiency and viability of the proposed system

Keywords

biology computing; cellular biophysics; haptic interfaces; microorganisms; rendering (computer graphics); advanced robotics; biological samples; biomechanical characterization; elastic properties exploration; haptic sensing device; human tumoral Epithilial Hella cells; in vitro cultured microscopic cells; microforce measurement; microforce sensing device; nanoforce measurement; nonlinear elasticity theory formalism; realistic elastic rendering; Cells (biology); Electrochemical machining; Haptic interfaces; Humans; In vitro; Mechanical factors; Mechanical variables measurement; Nanobioscience; Robot sensing systems; Scanning probe microscopy; Haptic sensing; In vitro mechanical cell characterization; Micro and nano-force measurement; Non-linear elastic properties of cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Virtual Environments, Human-Computer Interfaces and Measurement Systems, Proceedings of 2006 IEEE International Conference on

Conference_Location

La Coruna

Print_ISBN

1-4244-0242-5

Electronic_ISBN

1-4244-0243-3

Type

conf

DOI

10.1109/VECIMS.2006.250785

Filename

4016657