Title :
Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin
Author :
Samouillan, ValeÌrie ; Dandurand, Jany ; CausseÌ, Nicolas ; Lacabanne, Colette ; Bochicchio, Brigida ; Pepe, Antonietta
Author_Institution :
Polymer Phys., Paul Sabatier Univ., Toulouse, France
Abstract :
This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies. The comparison between the linear peptides and the associated amyloidlike fibers evidences the strong influence of the secondary structures on the physical structure and chain dynamics of these polypeptides.
Keywords :
biothermics; molecular biophysics; molecular configurations; polymers; amyloid-like fibers; dielectric characterization; human tropoelastin; human tropoelastin proteolysis; linear peptides; molecular mobility; neurodegenerative pathologies; polypeptide chain dynamics; polypeptide physical structure; secondary structures; synthetic peptide; thermal characterization; vibrational characterization; Dielectrics; Isothermal processes; Optical fiber networks; Optical fiber theory; Peptides; Spectroscopy; Temperature distribution; biological materials; calorimetry; infrared spectroscopy; permittivity measurements; thermally stimulated currents;
Journal_Title :
Dielectrics and Electrical Insulation, IEEE Transactions on
DOI :
10.1109/TDEI.2015.7116333
