Multifunctional neuroprobes with integrated chemical and electrical neural interfaces

Author

Kipke, D.R.

Author_Institution

Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA

Volume

4

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

3337

Abstract

This paper summarizes ongoing efforts in our laboratory to develop next-generation implantable neuroprobe systems that have closely integrated chemical and electrical neural interfaces. The MEMS-based neuroprobe consists of a silicon or polymer substrate having multiple metal sites for electrical recording and/or stimulation and one or more microchannels for fluid delivery. A chronoamperometric chemical sensor is achieved by selectively coating metal sites with an ion selective membrane. This multifunctional neuroprobe system provides a novel technology for establishing chronic and controllable chemical and electrical interfaces to targeted areas of the brain and spinal cord.

Keywords

amperometric sensors; biomembranes; brain; drug delivery systems; microelectrodes; microfluidics; neurophysiology; probes; prosthetics; silicon; MEMS-based neuroprobe; Si; bioMEMS; brain; chemical sensor; chronoamperometric chemical sensor; drug delivery; electrical neural interfaces; fluid delivery; implantable neuroprobe; integrated chemical interface; ion selective membrane; microchannels; multifunctional neuroprobes; neural prosthesis; polymer substrate; rnicroelectrode; selective coating; silicon; spinal cord; Biomembranes; Chemical sensors; Chemical technology; Coatings; Control systems; Laboratories; Microchannel; Polymers; Silicon; Spinal cord;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1280859

Filename

1280859