Linear system analysis of dynamic behavior of calcium ion channel by an allosteric model

Author

Hirayama, H. ; Yamazawa, H. ; Duenes, J.C. ; Fukuyama, Y.

Author_Institution

Dept. of Public health, Asahikawa Med. Coll., Japan

fYear

1997

fDate

29-31 Jul 1997

Firstpage

1161

Lastpage

1166

Abstract

Systemic properties of the calcium ionic channel in a biological membrane were investigated by linear system analysis. The transient behavior of the calcium ionic channel was expressed by four identical allosteric units which are voltage sensitive. A five open and closed states model was expressed by 10 linear state equations with conservation law. Linear system analysis disclosed that the system was stable but uncontrollable. Six singular values were insensitive to frequency. The linear system approach is useful to estimate the entire properties of the multiple states calcium ionic channels

Keywords

bioelectric phenomena; biomembrane transport; calcium; linear systems; physiological models; Ca; allosteric model; biological membrane; calcium ion channel; conservation law; dynamic behavior; linear state equations; linear system analysis; systemic properties; transient behavior; Biochemistry; Biological system modeling; Biomembranes; Biosensors; Calcium; Current measurement; Kinetic theory; Linear systems; Proteins; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

SICE '97. Proceedings of the 36th SICE Annual Conference. International Session Papers

Conference_Location

Tokushima

Type

conf

DOI

10.1109/SICE.1997.624960

Filename

624960