Title :
Linear system analysis of dynamic behavior of calcium ion channel by an allosteric model
Author :
Hirayama, H. ; Yamazawa, H. ; Duenes, J.C. ; Fukuyama, Y.
Author_Institution :
Dept. of Public health, Asahikawa Med. Coll., Japan
Abstract :
Systemic properties of the calcium ionic channel in a biological membrane were investigated by linear system analysis. The transient behavior of the calcium ionic channel was expressed by four identical allosteric units which are voltage sensitive. A five open and closed states model was expressed by 10 linear state equations with conservation law. Linear system analysis disclosed that the system was stable but uncontrollable. Six singular values were insensitive to frequency. The linear system approach is useful to estimate the entire properties of the multiple states calcium ionic channels
Keywords :
bioelectric phenomena; biomembrane transport; calcium; linear systems; physiological models; Ca; allosteric model; biological membrane; calcium ion channel; conservation law; dynamic behavior; linear state equations; linear system analysis; systemic properties; transient behavior; Biochemistry; Biological system modeling; Biomembranes; Biosensors; Calcium; Current measurement; Kinetic theory; Linear systems; Proteins; Voltage;
Conference_Titel :
SICE '97. Proceedings of the 36th SICE Annual Conference. International Session Papers
Conference_Location :
Tokushima
DOI :
10.1109/SICE.1997.624960
