Design of a turbulence-enhanced deaggregation system for dry powder formulations

Author

Teh, N.J. ; Sarvar, F. ; Conway, P.P.

Author_Institution

Wolfson Sch. of Mech. & Manuf. Eng., Loughborough Univ. of Technol., UK

Volume

4

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

3866

Abstract

This paper reports on the engineering design, manufacture and experimental analysis of a combined impaction and deaggregation delivery system for patient inspiration-driven pulmonary dry powder formulations. A modular technology platform has been designed and analysed with computational fluid dynamics analysis to investigate and optimise configurations of the device. The device was then manufactured in a modular form using rapid prototyping techniques to allow a range of impaction and deaggregation options to be investigated by experimental verification. Experimental investigation included twin stage impinger trials to assess fine particle fraction and fine particle dose capabilities and instrumentation of the device to determine fluid flow and flow resistance at a specified pressure drop of 4 kPa, allowing further optimisation of the device to patient inspiration capabilities.

Keywords

computational fluid dynamics; drug delivery systems; medicine; modular construction; pneumodynamics; powders; software prototyping; turbulence; 4 KPa; computational fluid dynamics analysis; deaggregation delivery system; device optimisation; dry powder formulations; flow resistance; fluid flow; impaction delivery system; modular technology platform; patient inspiration capability; patient inspiration-driven pulmonary dry powder formulations; rapid prototyping techniques; turbulence-enhanced deaggregation system; twin stage impinger trials; Biomedical informatics; Computational fluid dynamics; Design engineering; Design optimization; Drug delivery; Intelligent sensors; Lungs; Medical treatment; Powders; Pulp manufacturing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1281008

Filename

1281008