The genetic profile of a tumor as a determinant of its response to radiotherapy: a computer simulation of two different radiotherapeutic schemes

Author

Dionysiou, D.D. ; Peristeris, T. ; Stamatakos, G.S. ; Nikita, K.S. ; Uzunoglu, N.K.

Author_Institution

Sch. of Electr. & Comput. Eng., Nat. Tech. Univ. of Athens, Greece

Volume

2

fYear

2004

fDate

1-5 Sept. 2004

Firstpage

3035

Lastpage

3038

Abstract

The aim of this paper is to present comparative results of a tumor response to radiotherapy model, concerning two different fractionation schemes and the insulin-like growth factor I receptor expression. A clinical case of glioblastoma multiforme is selected. The model parameters are appropriately adjusted according to the literature. The results of the simulation procedure are three-dimensionally visualized and compared with clinical experience.

Keywords

cancer; cellular effects of radiation; digital simulation; genetics; medical computing; radiation therapy; tumours; cancer; computer simulation; genetic profile; glioblastoma multiforme; insulin-like growth factor I receptor expression; radiotherapeutic schemes; radiotherapy model; three-dimensional visualization; tumor response; Biological cells; Biological system modeling; Cancer; Computational modeling; Computer simulation; Genetics; Neoplasms; Niobium compounds; Phase estimation; Visualization; S imulation; cancer; modeling; radiotherapy; visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE

Conference_Location

San Francisco, CA

Print_ISBN

0-7803-8439-3

Type

conf

DOI

10.1109/IEMBS.2004.1403859

Filename

1403859