DocumentCode :
2737074
Title :
Poster: Gene regulatory network inference using time lagged context likelihood of relatedness
Author :
Chaitankar, Vijender ; Ghosh, Preetam ; Elasri, Mohamed O. ; Perkins, Edward J.
Author_Institution :
Sch. of Comput., Univ. of Southern Mississippi, Hattiesburg, MS, USA
fYear :
2011
fDate :
3-5 Feb. 2011
Firstpage :
236
Lastpage :
236
Abstract :
In our previous work, we have shown that time lags can be incorporated in information theory based metrics to further improve the efficiency of gene regulatory network inference. In particular, we have studied the mutual information metric where we found that mutual information saturates after a certain data size. We also proposed the time lagged mutual information metric and showed that the accuracy of inference algorithms using time lagged mutual information was better. Scalability of the proposed algorithm was an issue in our previous work. CLR is one of the popular algorithms which can infer very large networks. In this poster, we propose a time lagged version of the CLR algorithm.
Keywords :
biology computing; cellular biophysics; delays; genetics; inference mechanisms; information theory; molecular biophysics; gene regulatory network inference; information theory; mutual information metric; relatedness; scalability; time lagged context likelihood; time lags; Genetic communication; Inference algorithms; Measurement; Mutual information; Proteins; USA Councils; Information Theory; Regulatory networks; time-lags;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-61284-851-8
Type :
conf
DOI :
10.1109/ICCABS.2011.5729890
Filename :
5729890
Link To Document :
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