DocumentCode
2739421
Title
Directed Evolution of AAV Mutants for Enhanced Gene Delivery
Author
Schaffer, D.V. ; Maheshri, N. ; Schaffer, David V. ; Maheshri, N.
Author_Institution
Department of Chemical Engineering and the Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA
Volume
2
fYear
2004
fDate
1-5 Sept. 2004
Firstpage
3520
Lastpage
3523
Abstract
Gene therapy vehicles must be engineered to overcome numerous barriers that limit delivery efficiency. These barriers arise at every step of the delivery process, including the transit of the vector from injection to a cell surface, re ceptor binding and uptake, intracellular trafficking, and nuclear entry. The gene transfer properties of the highly promising adeno-associated viral (AAV) vector at each step are determined by its capsid structure.
Keywords
AAV; directed evolution; gene delivery; viral vector; Assembly; Bioinformatics; DNA; Genomics; Humans; Libraries; Medical treatment; Packaging; Proteins; Rabbits;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Print_ISBN
0-7803-8439-3
Type
conf
DOI
10.1109/IEMBS.2004.1403990
Filename
1403990
Link To Document