Oxidized LDL as an Effective Anti-Cancer Bio Nanoparticle

Author

Wang, Pei-Wen ; Chen, Chu-Huang ; Shieh, Dar-Bin

Author_Institution

Inst. of Basic Med. Sci., Nat. Cheng Kung Univ., Tainan

fYear

2008

fDate

18-21 Aug. 2008

Firstpage

673

Lastpage

674

Abstract

Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor cells ongoing apoptosis. Measurement of mitochondrial membrane potential (Deltapsi) revealed a significant loss of the Deltapsi upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.

Keywords

biomembranes; cancer; cardiovascular system; cellular biophysics; dosimetry; lipid bilayers; nanoparticles; oxidation; proteins; tumours; anticancer drug carrier; apoptosis; arthrosclerosis; auto-oxidation; cancer cell; cardiovascular diseases; chemotherapeutic agent; effective anticancer bio nanoparticle; endothelial cell apoptosis; endothelial cells; lipid metabolism; low density lipoproteins; mitochondrial membrane potential; oxidized LDL; tumor cells; Biochemistry; Biomembranes; Cancer; Cardiovascular diseases; Educational institutions; Fluorescence; Lipidomics; Loss measurement; Nanoparticles; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology, 2008. NANO '08. 8th IEEE Conference on

Conference_Location

Arlington, TX

Print_ISBN

978-1-4244-2103-9

Electronic_ISBN

978-1-4244-2104-6

Type

conf

DOI

10.1109/NANO.2008.203

Filename

4617185