A bio-amplifier with pulse output

Author

Du Chen ; Harris, John G. ; Principe, Jose C.

Author_Institution

Dept. of Electr. & Comput. Eng., Florida Univ., Gainesville, FL, USA

Volume

2

fYear

2004

fDate

1-5 Sept. 2004

Firstpage

4071

Lastpage

4074

Abstract

A low-power fully integrated bioamplifier is presented that can amplify signals in the range from mHz to kHz while rejecting large DC offsets generated at the electrode-tissue interface. The novel aspect of this amplifier is that its analog output is represented by a series of pulses which provide a low-power, noise-resistant means for coding and transmission. The original analog signal can be reconstructed from the resulting pulse train with 13 bit precision at a remote site where power consumption is not so crucial. The fabricated analog amplifier exhibits a gain of 39.5 dB from 0.3 Hz to 5.4k Hz. The power consumption of the whole system is less than 300 μW/channel from a 5-V supply. The fully integrated system was designed in the AMI 0.6 μm CMOS process and it consumes 0.088 mm²/channel of chip area.

Keywords

CMOS analogue integrated circuits; bioelectric phenomena; biological tissues; biomedical electrodes; brain; microelectrodes; neurophysiology; pulse amplifiers; 0.3 to 5.4 Hz; 39.5 dB; 5 V; CMOS process; bio-amplifier; electrode-tissue interface; low-power fully integrated bioamplifier; low-power noise-resistant coding; low-power noise-resistant transmission; pulse output; Biomedical electrodes; CMOS process; Circuit noise; Energy consumption; Extracellular; Neurons; Preamplifiers; Pulse amplifiers; Pulse circuits; Signal processing; : Bio-amplifier; CMOS; low power; pulse train;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE

Conference_Location

San Francisco, CA

Print_ISBN

0-7803-8439-3

Type

conf

DOI

10.1109/IEMBS.2004.1404136

Filename

1404136