THz Time-Domain Spectroscopy of Thin-Film DNA Oligomer Having Mismatch

THz spectroscopy and imaging is useful for hybridization assessment compared with conventional methods using fluorescence indicators, because THz method can give the hybridization information without any indicators. We have successfully obtained the THz spectrum using 11mers having G-G mismatch and found a very clear peak structure in the spectrum. We also report the THz spectra of 11mers with naphthyridine dimmer binding to G-G mismatch.