Title :
Simulation of radioactive gold nanoparticles functionalized with Gum Arabic glycoprotein in liver cancer therapy
Author :
Alizadeh, Mahdi ; Qaradaghi, Vahid
Author_Institution :
Dept. of Bioeng., Temple Univ., Philadelphia, PA, USA
Abstract :
The therapeutic properties of radioactive gold nanoparticles (198-AuNPs) (βmax=0.96 MeV, t1/2=2.7 days) and target specific biomolecule were used to form a powerful radiopharmaceutical for targeted drug delivery. The pharmacokinetics and biodistribution studies of Gum Arabic (GA) glycoprotein coated 198-AuNPs in mice showed greater than 80% uptake in the liver with minimal accumulation in blood and other organs. In this paper, energy deposition of GA-198-AuNPs in tumors with different sizes was simulated using Monte Carlo simulation. For simplicity, it is assumed that the distribution of AuNPs is surface distribution which means all NPs accumulate at the surface of the tumor. GA glycoprotein functionalized gold nanoparticles (AuNPs) possess optimized sizes (12-18 nm core diameter and 85 nm hydrodynamic diameter) to target individual tumor cells. The simulation shows activities and absorbed doses in the tumors with 0.25cm and 0.5cm radius were 187.9mCi, 72Gy and 300mCi, 118 Gy respectively.
Keywords :
Monte Carlo methods; biochemistry; biomedical materials; cancer; cellular biophysics; drug delivery systems; gold; hydrodynamics; liver; molecular biophysics; nanomedicine; nanoparticles; proteins; tumours; Au; Gum Arabic glycoprotein; Monte Carlo simulation; biodistribution studies; blood; electron volt energy 0.96 MeV; energy deposition; hydrodynamic diameter; liver cancer therapy; pharmacokinetic studies; radioactive gold nanoparticle functionalization; radiopharmaceutical; size 12 nm to 18 nm; size 85 nm; surface distribution; target specific biomolecule; targeted drug delivery; time 2.7 day; tumor cells; Cancer; Gold; Liver; Medical treatment; Monte Carlo methods; Nanoparticles; Tumors; Monte Carlo; cancer; molecular therapy; radioactive gold nanoparticles;
Conference_Titel :
Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast
Conference_Location :
Troy, NY
Print_ISBN :
978-1-4799-8358-2
DOI :
10.1109/NEBEC.2015.7117068