Biotranport and biocompatibility of nanoporous biocapsules

Author

Leoni, Lara ; Desai, Tejal A.

Author_Institution

Dept. of Bioeng., Illinois Univ., Chicago, IL, USA

fYear

2000

fDate

2000

Firstpage

113

Lastpage

117

Abstract

This study investigates whether nanoporous micromachined biocapsules, with uniform membrane pore sizes of 24.5 nm, can be used to encapsulate insulin secreting cells in vitro. This approach to cell encapsulation is based on microfabrication technology whereby immunoisolation membranes are bulk and surface micromachined to present uniform and well-controlled pore sizes as small as 10 nanometers, tailored surface chemistries, and precise microarchitectures. This study evaluates the behavior of insulinoma cells with micromachined membranes, the effect of matrix configurations within the biocapsule on cell behavior, as well as insulin and glucose transport through the biocapsule membranes

Keywords

biomembrane transport; encapsulation; micromachining; patient treatment; 10 nm; 24.5 nm; biocapsule membranes; biocompatibility; cell behavior; cell encapsulation; glucose transport; insulin secreting cells; insulin transport; matrix configurations effect; nanoporous micromachined biocapsules; tailored surface chemistries; Biomembranes; Chemical technology; Chemistry; Encapsulation; Immune system; In vitro; Insulin; Microarchitecture; Nanoporous materials; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnologies in Medicine and Biology, 1st Annual International, Conference On. 2000

Conference_Location

Lyon

Print_ISBN

0-7803-6603-4

Type

conf

DOI

10.1109/MMB.2000.893753

Filename

893753