Hardware simulation of yeast glycolytic oscillations

This paper presents the design of a hardware simulator of biological processes described by chemical-kinetic equations. The simulator is made up of processing elements that use floating point arithmetic and a pipeline architecture. Due to its compact design, several processing elements can be synthesized into a single FPGA to create a multiprocessing architecture allowing the parallel simulation of several biological processes that are executed simultaneously, and thus, reducing the execution time with respect to software simulations. The design was verified simulating two models: yeast glycolytic oscillations and induced glycolytic oscillations between two cells. The obtained results prove that the architecture designed is suitable to simulate complex biological processes in lower times than in software simulations.