Title :
Tissue specific methylation and genotype
Author :
Kinoshita, Ryoichi ; Taguchi, Y.-H.
Author_Institution :
Dept. of Phys., Chuo Univ., Tokyo, Japan
Abstract :
It is unclear how genotype affects methylation. In this paper, we have applied principal component analysis to both genotype and methylation on tumor, adjacent normal tissue, and blood DNA from 30 patients. Dominant pattern turns out to be upregulation from blood to tumor through tissue for both genotype and methylation. Overlap between significantly upregulating genotype and methylated genes are significantly overlaped. Thus, at least, for some regions, genotype correlates to methylation.
Keywords :
DNA; biochemistry; biological tissues; blood; cellular biophysics; molecular biophysics; principal component analysis; tumours; blood DNA; genes; genotype; principal component analysis; tissue specific methylation; tumor; Bioinformatics; Conferences;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on
Conference_Location :
Atlanta, GA
Print_ISBN :
978-1-4577-1612-6
DOI :
10.1109/BIBMW.2011.6112517
