• DocumentCode
    2767273
  • Title

    Tissue specific methylation and genotype

  • Author

    Kinoshita, Ryoichi ; Taguchi, Y.-H.

  • Author_Institution
    Dept. of Phys., Chuo Univ., Tokyo, Japan
  • fYear
    2011
  • fDate
    12-15 Nov. 2011
  • Firstpage
    953
  • Lastpage
    955
  • Abstract
    It is unclear how genotype affects methylation. In this paper, we have applied principal component analysis to both genotype and methylation on tumor, adjacent normal tissue, and blood DNA from 30 patients. Dominant pattern turns out to be upregulation from blood to tumor through tissue for both genotype and methylation. Overlap between significantly upregulating genotype and methylated genes are significantly overlaped. Thus, at least, for some regions, genotype correlates to methylation.
  • Keywords
    DNA; biochemistry; biological tissues; blood; cellular biophysics; molecular biophysics; principal component analysis; tumours; blood DNA; genes; genotype; principal component analysis; tissue specific methylation; tumor; Bioinformatics; Conferences;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on
  • Conference_Location
    Atlanta, GA
  • Print_ISBN
    978-1-4577-1612-6
  • Type

    conf

  • DOI
    10.1109/BIBMW.2011.6112517
  • Filename
    6112517
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2767273