Magnetic resonance angiography study of a normal mouse brain for creating a three-dimensional cerebral vasculature atlas and software for labeling vessels

In our lab, we are studying a mouse model of Hereditary Hemorrhagic Telangiectasia (HHT), a genetic disorder that leads to ArterioVenous Malformations (AVMs) in brain. Using this mouse model and the technique of Magnetic Resonance Angiography (MRA), we are pursuing the goal of tracking AVMs to determine a classification system that stratifies AVMs by longitudinal evolution. Before this work can occur, we need to build a three-dimensional (3D) MRA Atlas for a healthy normal mouse brain for comparison. The 3D atlas we have built presents the vascular structure for the healthy normal mouse brain using a graphical software tool.